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NEFM

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Identifiers
SymbolsNEFM ; NEF3; NF-M; NFM
External IDsOMIM162250 MGI97314 HomoloGene38041 GeneCards: NEFM Gene
RNA expression pattern
File:PBB GE NEFM 205113 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez474118040
EnsemblENSG00000104722ENSMUSG00000022054
UniProtP07197P08553
RefSeq (mRNA)NM_001105541NM_008691
RefSeq (protein)NP_001099011NP_032717
Location (UCSC)Chr 8:
24.77 – 24.78 Mb
Chr 14:
68.08 – 68.12 Mb
PubMed search[1][2]

Neurofilament medium polypeptide (NF-M) is a protein that in humans is encoded by the NEFM gene.[1][2]

Function

Neurofilaments are type IV intermediate filament heteropolymers composed of light (NEFL), medium (this protein), and heavy (NEFH) chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage.[2]

References

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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