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NEUROD2

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Identifiers
SymbolsNEUROD2 ; NDRF; bHLHa1
External IDsOMIM601725 MGI107755 HomoloGene4489 GeneCards: NEUROD2 Gene
RNA expression pattern
File:PBB GE NEUROD2 210271 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez476118013
EnsemblENSG00000171532ENSMUSG00000038255
UniProtQ15784Q62414
RefSeq (mRNA)NM_006160NM_010895
RefSeq (protein)NP_006151NP_035025
Location (UCSC)Chr 17:
37.76 – 37.77 Mb
Chr 11:
98.33 – 98.33 Mb
PubMed search[1][2]

Neurogenic differentiation factor 2 is a protein that in humans is encoded by the NEUROD2 gene.[1][2]

This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.[2]

Interactions

NEUROD2 has been shown to interact with Protein kinase N1.[3]

References

  1. ^ Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ (Apr 1997). "NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively". Genomics 40 (2): 355–7. PMID 9119405. doi:10.1006/geno.1996.4578. 
  2. ^ a b "Entrez Gene: NEUROD2 neurogenic differentiation 2". 
  3. ^ Shibata, H; Oda H; Mukai H; Oishi K; Misaki K; Ohkubo H; Ono Y (Dec 1999). "Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Res. Mol. Brain Res. (NETHERLANDS) 74 (1–2): 126–34. ISSN 0169-328X. PMID 10640683. doi:10.1016/S0169-328X(99)00273-9. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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