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NFYA

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsNFYA ; CBF-A; CBF-B; HAP2; NF-YA
External IDsOMIM189903 MGI97316 HomoloGene32114 GeneCards: NFYA Gene
RNA expression pattern
File:PBB GE NFYA 204109 s at tn.png
File:PBB GE NFYA 204107 at tn.png
File:PBB GE NFYA 204108 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez480018044
EnsemblENSG00000001167ENSMUSG00000023994
UniProtP23511P23708
RefSeq (mRNA)NM_002505NM_001110832
RefSeq (protein)NP_002496NP_001104302
Location (UCSC)Chr 6:
41.04 – 41.07 Mb
Chr 17:
48.39 – 48.41 Mb
PubMed search[1][2]

Nuclear transcription factor Y subunit alpha is a protein that in humans is encoded by the NFYA gene.[1][2]

Function

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.[3]

Interactions

NFYA has been shown to interact with Serum response factor[4] and ZHX1.[4][5]

References

  1. ^ Li XY, Mattei MG, Zaleska-Rutczynska Z, Hooft van Huijsduijnen R, Figueroa F, Nadeau J et al. (Mar 1992). "One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes". Genomics 11 (3): 630–4. PMID 1774067. doi:10.1016/0888-7543(91)90070-U. 
  2. ^ Maity SN, de Crombrugghe B (Jun 1998). "Role of the CCAAT-binding protein CBF/NF-Y in transcription". Trends Biochem Sci 23 (5): 174–8. PMID 9612081. doi:10.1016/S0968-0004(98)01201-8. 
  3. ^ "Entrez Gene: NFYA nuclear transcription factor Y, alpha". 
  4. ^ a b Yamada K, Osawa H, Granner DK (Oct 1999). "Identification of proteins that interact with NF-YA". FEBS Lett. 460 (1): 41–5. PMID 10571058. doi:10.1016/S0014-5793(99)01311-3. 
  5. ^ Yamada K, Printz RL, Osawa H, Granner DK (Aug 1999). "Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y". Biochem. Biophys. Res. Commun. 261 (3): 614–21. PMID 10441475. doi:10.1006/bbrc.1999.1087. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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