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NFYC

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Identifiers
SymbolsNFYC ; CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC
External IDsOMIM605344 MGI107901 HomoloGene7440 GeneCards: NFYC Gene
RNA expression pattern
File:PBB GE NFYC 202215 s at tn.png
File:PBB GE NFYC 202216 x at tn.png
File:PBB GE NFYC 211251 x at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez480218046
EnsemblENSG00000066136ENSMUSG00000032897
UniProtQ13952P70353
RefSeq (mRNA)NM_001142587NM_001048168
RefSeq (protein)NP_001136059NP_001041633
Location (UCSC)Chr 1:
41.16 – 41.24 Mb
Chr 4:
120.76 – 120.83 Mb
PubMed search[1][2]

Nuclear transcription factor Y subunit gamma is a protein that in humans is encoded by the NFYC gene.[1][2][3]

Function

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit C, forms a tight dimer with the B subunit (NFYB), a prerequisite for subunit A (NFYA) association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. Additional regulation, preliminarily supported by the EST database, may be represented by alternative splicing in this subunit.[3]

Two microRNAs; miR-30c and miR-30e are located within introns of the nfyc gene. These microRNAs are actively transcribed in human insulin-producing beta cells in the pancreatic islets that also show high expression of nfyc and CDH1 genes. The expression of these intronic microRNAs is essential for maintaining the differentiated phenotype of human islet beta cells. Inhibition of miR-30 family microRNAs induces epithelial-mesenchymal transition of human pancreatic islet cells.[4]

Interactions

NFYC has been shown to interact with Myc.[5]

References

  1. ^ Sinha S, Maity SN, Seldin MF, de Crombrugghe B (Feb 1997). "Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor". Genomics 37 (2): 260–3. PMID 8921405. doi:10.1006/geno.1996.0555. 
  2. ^ Bellorini M, Zemzoumi K, Farina A, Berthelsen J, Piaggio G, Mantovani R (Aug 1997). "Cloning and expression of human NF-YC". Gene 193 (1): 119–25. PMID 9249075. doi:10.1016/S0378-1119(97)00109-1. 
  3. ^ a b "Entrez Gene: NFYC nuclear transcription factor Y, gamma". 
  4. ^ Joglekar MV, Patil D, Joglekar VM, Rao GV, Reddy DN, Mitnala S et al. (September–October 2009). "The miR-30 family microRNAs confer epithelial phenotype to human pancreatic cells". Islets 1 (2): 137–147. PMID 21099261. doi:10.4161/isl.1.2.9578. 
  5. ^ Taira T, Sawai M, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H (August 1999). "Cell cycle-dependent switch of up-and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y". J. Biol. Chem. 274 (34): 24270–9. PMID 10446203. doi:10.1074/jbc.274.34.24270. 

Further reading

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External links

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