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Open Access Articles- Top Results for NKX3-2

NKX3-2

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Identifiers
SymbolsNKX3-2 ; BAPX1; NKX3.2; NKX3B; SMMD
External IDsOMIM602183 HomoloGene68168 GeneCards: NKX3-2 Gene
Orthologs
SpeciesHumanMouse
Entrez57912020
EnsemblENSG00000109705ENSMUSG00000049691
UniProtP78367P97503
RefSeq (mRNA)NM_001189NM_007524
RefSeq (protein)NP_001180NP_031550
Location (UCSC)Chr 4:
13.54 – 13.55 Mb
Chr 5:
41.76 – 41.76 Mb
PubMed search[1][2]

NK3 homeobox 2 also known as NKX3-2 is a human gene. It is a homolog of bagpipe(bap) in Drosophila and therefore also known as Bapx1 (bagpipe homeobox homolog 1) . The protein encoded by this gene is a homeo domain containing transcription factor.[1]

Function

NKX3-2 plays a role in the development of the skeleton.[2] Nkx3-2 in mice also regulates patterning in the middle ear.[3]

References

  1. ^ Yoshiura KI, Murray JC (October 1997). "Sequence and chromosomal assignment of human BAPX1, a bagpipe-related gene, to 4p16.1: a candidate gene for skeletal dysplasia". Genomics 45 (2): 425–8. PMID 9344671. doi:10.1006/geno.1997.4926. 
  2. ^ Lettice L, Hecksher-Sørensen J, Hill R (2001). "The role of Bapx1 (Nkx3.2) in the development and evolution of the axial skeleton". J. Anat. 199 (Pt 1–2): 181–7. PMC 1594973. PMID 11523821. doi:10.1111/j.1469-7580.2008.00944.x. 
  3. ^ Tucker AS, Watson RP, Lettice LA, Yamada G, Hill RE (2004). "Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution". Development 131 (6): 1235–1245. PMID 14973294. doi:10.1242/dev.01017. 

External links

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