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Nafoxidine

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Nafoxidine
File:Nafoxidine.png
Systematic (IUPAC) name
1-[2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl]pyrrolidine
Clinical data
Identifiers
1845-11-0
None
PubChem CID 4416
ChemSpider 4263
UNII 4RIY10WM82 7pxY
ChEMBL CHEMBL28211
Chemical data
Formula C29H31NO2
425.562 g/mol

Nafoxidine (U-11,000A) is a non-steroidal antiestrogenic drug that has been investigated to treat advanced breast cancer.[1] It is structurally related to tamoxifen.

The drug is one of a series of similar structures invented at Upjohn. An earlier compound known as U-11,555 is related to Nafoxidine was found to cause photosensitivity in human volunteers.[2][3]

References

  1. ^ Steinbaum, F. L.; De Jager, R.; Krakoff, I. (1978). "Clinical trial of nafoxidine in advanced breast cancer". Medical and Pediatric Oncology 4 (2): 123–126. PMID 661750. doi:10.1002/mpo.2950040207.  edit
  2. ^ http://www.sciencebase.com/serendipity_and_science.html
  3. ^ Lednicer,, D.; Babcock, J.C.; Marlatt, P.E.; Lyster, S.C.; Duncan, G.W. (1965). "Mammalian Antifertility Agents. I. Derivatives of 2,3-Diphenylindenes". J. Med. Chem. 8 (1): 52–57. doi:10.1021/jm00325a013. 


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