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Naftifine

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Naftifine
File:Naftifine.svg
Systematic (IUPAC) name
(2E)-N-methyl-N-(1-naphthylmethyl)-3-phenylprop-2-en-1-amine
Clinical data
Trade names Naftin
AHFS/Drugs.com monograph
MedlinePlus a688020
Identifiers
65472-88-0 7pxY
D01AE22
PubChem CID 47641
DrugBank DB00735 7pxY
ChemSpider 66071 7pxN
UNII 4FB1TON47A 7pxN
ChEBI CHEBI:7451 7pxN
ChEMBL CHEMBL626 7pxN
Chemical data
Formula C21H21N
287.398 g/mol
 14pxN (what is this?)  (verify)

Naftifine (brand name Naftin) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections).

Its precise mechanism of action is unknown, but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme.[1][2] The half-life is approximately 2–3 days.[2] The metabolites are excreted in the urine and feces.[3]

Synthesis

References

  1. ^ Robertson Dirk B, Maibach Howard I, "Chapter 61. Dermatologic Pharmacology" (Chapter). Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor: Basic & Clinical Pharmacology, 11e: http://www.accesspharmacy.com/content.aspx?aID=4517257.
  2. ^ a b Micromedex DRUGDEX Drug Point: Naftifine Hydrochloride. Accessed at www.thomsonhc.com/../BeginWith#secN10184, February 18, 2010.
  3. ^ AccessPharmacy: Drug Monographs: Naftifine. Accessed at http://www.accesspharmacy.com/drugContentPopup.aspx?mid=6620&section=10, February 18, 2010.
  4. ^ Template:Cite doi/10.1016.2FS0040-4039.2801.2981224-7 edit

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