Open Access Articles- Top Results for Nantenine


Systematic (IUPAC) name
Clinical data
2565-01-7 7pxY
PubChem CID 197001
ChemSpider 170619 7pxN
ChEMBL CHEMBL467094 7pxN
Chemical data
Formula C20H21NO4
339.385 g/mol
 14pxN (what is this?)  (verify)

Nantenine is an alkaloid found in the plant Nandina domestica[1] as well as some Corydalis species.[2] It is an antagonist at both the α1 adrenergic receptor[3] and the 5-HT2A serotonin receptor,[4] and blocks both the behavioural and physiological effects of MDMA in animals.[5]

See also


  1. ^ Shoji N, Umeyama A, Takemoto T, Ohizumi Y (April 1984). "Serotonergic receptor antagonist from Nandina domestica Thunberg". Journal of Pharmaceutical Sciences 73 (4): 568–70. PMID 6726648. doi:10.1002/jps.2600730435. 
  2. ^ Kiryakov HG, Iskrenova E, Daskalova E, Kuzmanov B, Evstatieva L (March 1982). "Alkaloids of Corydalis slivenensis". Planta Medica 44 (3): 168–70. PMID 17402105. doi:10.1055/s-2007-971432. 
  3. ^ Indra B, Matsunaga K, Hoshino O, Suzuki M, Ogasawara H, Ohizumi Y (February 2002). "Structure-activity relationship studies with (+/-)-nantenine derivatives for alpha1-adrenoceptor antagonist activity". European Journal of Pharmacology 437 (3): 173–8. PMID 11890906. doi:10.1016/S0014-2999(02)01303-1. 
  4. ^ Chaudhary S, Pecic S, Legendre O, Navarro HA, Harding WW (May 2009). "(+/-)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congeners". Bioorganic & Medicinal Chemistry Letters 19 (9): 2530–2. PMC 2677726. PMID 19328689. doi:10.1016/j.bmcl.2009.03.048. 
  5. ^ Fantegrossi WE, Kiessel CL, Leach PT, Van Martin C, Karabenick RL, Chen X, Ohizumi Y, Ullrich T, Rice KC, Woods JH (May 2004). "Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice". Psychopharmacology 173 (3-4): 270–7. PMID 14740148. doi:10.1007/s00213-003-1741-2. 

Lua error in package.lua at line 80: module 'Module:Buffer' not found.