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Nervonic acid

Nervonic acid[1]
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IUPAC name
(Z)-Tetracos-15-enoic acid
Other names
cis-15-Tetracosenoic acid
24:1 cis, delta 15 or 24:1 omega 9
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506-37-6 7pxN
ChEBI CHEBI:44247 7pxY
ChEMBL ChEMBL1173379 7pxY
ChemSpider 4444565 7pxY
Jmol-3D images Image
KEGG C08323 7pxY
PubChem Template:Chembox PubChem/format
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C24H46O2
Molar mass 366.62 g/mol
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Nervonic acid is a monounsaturated omega-9 fatty acid. Nervonic acid has been identified as important in the biosynthesis of nerve cell myelin.[2] It is found in the sphingolipids of white matter in human brain.

Nervonic acid is used in the treatment of disorders involving demyelination, such as adrenoleukodystrophy and multiple sclerosis where there is a decreased level of nervonic acid in sphingolipids.[3]

Dietary sources

Nervonic acid is abundant in king salmon (a.k.a. Chinook salmon) with 140 mg/100g, yellow mustard seed (83 mg/100g), flaxseed (64 mg/100g), sockeye salmon (40 mg/100g), sesame seed (35 mg/100g), and macadamia nuts (18 mg/100g). [4]

References

  1. ^ Nervonic acid at Sigma-Aldrich
  2. ^ US Patent 6664406, Nervonic acid derivatives, their preparation and use
  3. ^ WO/1996/005740, Nervonic Acid Compositions
  4. ^ http://nutritiondata.self.com/foods-000046000000000000000-w.html

Additional references

  • Appelqvist (1976) Lipids in Cruciferae. In: Vaughan JG, Macleod AJ (Eds), The biology and the Chemistry of Cruciferae. Academic Press, London, UK, pp. 221-277.
  • Sargent JR, Coupland K, Wilson R (1994). Nervonic Acid and Demyelinating Disease. Medical Hypothesese 42, pp. 237-242.