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Open Access Articles- Top Results for Neuron-derived orphan receptor 1

Neuron-derived orphan receptor 1

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Identifiers
SymbolsNR4A3 ; CHN; CSMF; MINOR; NOR1; TEC
External IDsOMIM600542 MGI1352457 HomoloGene5074 IUPHAR: 631 GeneCards: NR4A3 Gene
RNA expression pattern
File:PBB GE NR4A3 207978 s at tn.png
File:PBB GE NR4A3 209959 at tn.png
File:PBB GE NR4A3 216979 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez801318124
EnsemblENSG00000119508ENSMUSG00000028341
UniProtQ92570Q9QZB6
RefSeq (mRNA)NM_006981NM_015743
RefSeq (protein)NP_008912NP_056558
Location (UCSC)Chr 9:
102.58 – 102.63 Mb
Chr 4:
48.05 – 48.09 Mb
PubMed search[1][2]

The neuron-derived orphan receptor 1 (NOR1) also known as NR4A3 (nuclear receptor subfamily 4, group A, member 3) is a protein that in humans is encoded by the NR4A3 gene.[1] NOR1 is a member of the nuclear receptor family of intracellular transcription factors.

NOR1 plays a central regulatory role in cell proliferation, differentiation, metabolism[2][3] and apoptosis[4]

Interactions

Neuron-derived orphan receptor 1 has been shown to interact with SIX3.[5][6]

See also

References

  1. ^ Hedvat CV, Irving SG (1995). "The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor". Mol. Endocrinol. 9 (12): 1692–700. PMID 8614405. doi:10.1210/me.9.12.1692. 
  2. ^ Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE (2006). "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology 147 (11): 5217–27. PMID 16901967. doi:10.1210/en.2006-0447. 
  3. ^ Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE (2008). "The Orphan Nuclear Receptor, NOR-1, a Target of {beta}-Adrenergic Signaling, Regulates Gene Expression that Controls Oxidative Metabolism in Skeletal Muscle". Endocrinology 149 (6): 2853–65. PMID 18325999. doi:10.1210/en.2007-1202. 
  4. ^ Nomiyama T, Nakamachi T, Gizard F, Heywood EB, Jones KL, Ohkura N, Kawamori R, Conneely OM, Bruemmer D (2006). "The NR4A Orphan Nuclear Receptor NOR1 Is Induced by Platelet-derived Growth Factor and Mediates Vascular Smooth Muscle Cell Proliferation". J. Biol. Chem. 281 (44): 33467–76. PMC 1829169. PMID 16945922. doi:10.1074/jbc.M603436200. 
  5. ^ Laflamme C, Filion C, Bridge JA, Ladanyi M, Goldring MB, Labelle Y (January 2003). "The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas". Cancer Res. 63 (2): 449–54. PMID 12543801. 
  6. ^ Ohkura N, Ohkubo T, Maruyama K, Tsukada T, Yamaguchi K (2001). "The orphan nuclear receptor NOR-1 interacts with the homeobox containing protein Six3". Dev. Neurosci. 23 (1): 17–24. PMID 11173923. doi:10.1159/000048692. 

Further reading

  • Ohkura N, Hijikuro M, Yamamoto A, Miki K (1995). "Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells". Biochem. Biophys. Res. Commun. 205 (3): 1959–65. PMID 7811288. doi:10.1006/bbrc.1994.2900. 
  • Clark J, Benjamin H, Gill S et al. (1996). "Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma". Oncogene 12 (2): 229–35. PMID 8570200. 
  • Labelle Y, Zucman J, Stenman G et al. (1996). "Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation". Hum. Mol. Genet. 4 (12): 2219–26. PMID 8634690. doi:10.1093/hmg/4.12.2219. 
  • Ohkura N, Ito M, Tsukada T et al. (1996). "Structure, mapping and expression of a human NOR-1 gene, the third member of the Nur77/NGFI-B family". Biochim. Biophys. Acta 1308 (3): 205–14. PMID 8809112. doi:10.1016/0167-4781(96)00101-7. 
  • Ohkura N, Ito M, Tsukada T et al. (1998). "Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA". Gene 211 (1): 79–85. PMID 9573341. doi:10.1016/S0378-1119(98)00095-X. 
  • Labelle Y, Bussières J, Courjal F, Goldring MB (1999). "The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator". Oncogene 18 (21): 3303–8. PMID 10359536. doi:10.1038/sj.onc.1202675. 
  • Panagopoulos I, Mencinger M, Dietrich CU et al. (2000). "Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11)". Oncogene 18 (52): 7594–8. PMID 10602519. doi:10.1038/sj.onc.1203155. 
  • Sjögren H, Wedell B, Meis-Kindblom JM et al. (2001). "Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21)". Cancer Res. 60 (24): 6832–5. PMID 11156374. 
  • Liu D, Jia H, Holmes DI et al. (2004). "Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1". Arterioscler. Thromb. Vasc. Biol. 23 (11): 2002–7. PMID 14525795. doi:10.1161/01.ATV.0000098644.03153.6F. 
  • Rius J, Martínez-González J, Crespo J, Badimon L (2004). "Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL-induced mitogenic stimulus in vascular smooth muscle cells: role of CREB". Arterioscler. Thromb. Vasc. Biol. 24 (4): 697–702. PMID 14962944. doi:10.1161/01.ATV.0000121570.00515.dc. 
  • Humphray SJ, Oliver K, Hunt AR et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. PMC 2734081. PMID 15164053. doi:10.1038/nature02465. 
  • Hisaoka M, Okamoto S, Yokoyama K, Hashimoto H (2004). "Coexpression of NOR1 and SIX3 proteins in extraskeletal myxoid chondrosarcomas without detectable NR4A3 fusion genes". Cancer Genet. Cytogenet. 152 (2): 101–7. PMID 15262426. doi:10.1016/j.cancergencyto.2003.11.011. 
  • Laflamme C, Filion C, Labelle Y (2005). "Functional characterization of SIX3 homeodomain mutations in holoprosencephaly: interaction with the nuclear receptor NR4A3/NOR1". Hum. Mutat. 24 (6): 502–8. PMID 15523651. doi:10.1002/humu.20102. 
  • Rius J, Martínez-González J, Crespo J, Badimon L (2006). "NOR-1 is involved in VEGF-induced endothelial cell growth". Atherosclerosis 184 (2): 276–82. PMID 15949808. doi:10.1016/j.atherosclerosis.2005.04.008. 
  • Pei L, Castrillo A, Chen M et al. (2005). "Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli". J. Biol. Chem. 280 (32): 29256–62. PMID 15964844. doi:10.1074/jbc.M502606200. 
  • Bonta PI, van Tiel CM, Vos M et al. (2006). "Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses". Arterioscler. Thromb. Vasc. Biol. 26 (10): 2288–94. PMID 16873729. doi:10.1161/01.ATV.0000238346.84458.5d. 
  • Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE (2006). "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology 147 (11): 5217–27. PMID 16901967. doi:10.1210/en.2006-0447. 
  • Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE (2008). "The Orphan Nuclear Receptor, NOR-1, a Target of {beta}-Adrenergic Signaling, Regulates Gene Expression that Controls Oxidative Metabolism in Skeletal Muscle". Endocrinology 149 (6): 2853–65. PMID 18325999. doi:10.1210/en.2007-1202. 
  • Vacca M, Murzilli S, Salvatore S et al. (2013). "Neuron-derived orphan receptor 1 promotes proliferation of quiescent hepatocytes". Gastroenterology 144 (7): 1518–1529. PMID 23462179. doi:10.1053/j.gastro.2013.02.027. 
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