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Open Access Articles- Top Results for Neuropeptide Y receptor Y5

Neuropeptide Y receptor Y5

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Identifiers
SymbolsNPY5R ; NPY5-R; NPYR5; NPYY5-R
External IDsOMIM602001 MGI108082 HomoloGene21241 IUPHAR: 308 ChEMBL: 4561 GeneCards: NPY5R Gene
RNA expression pattern
File:PBB GE NPY5R 207400 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez488918168
EnsemblENSG00000164129ENSMUSG00000044014
UniProtQ15761O70342
RefSeq (mRNA)NM_006174NM_016708
RefSeq (protein)NP_006165NP_057917
Location (UCSC)Chr 4:
164.27 – 164.27 Mb
Chr 8:
66.68 – 66.69 Mb
PubMed search[1][2]

Neuropeptide Y receptor type 5 is a protein that in humans is encoded by the NPY5R gene.[1][2][3]


Selective Ligands

Agonists

  • Neuropeptide Y (endogenous agonist, non subtype selective)
  • BWX-46 (selective NPY5 agonist, CAS# 172997-92-1)
  • Peptide YY

Antagonists

See also

References

  1. ^ Gerald C, Walker MW, Criscione L, Gustafson EL, Batzl-Hartmann C, Smith KE, Vaysse P, Durkin MM, Laz TM, Linemeyer DL, Schaffhauser AO, Whitebread S, Hofbauer KG, Taber RI, Branchek TA, Weinshank RL (Aug 1996). "A receptor subtype involved in neuropeptide-Y-induced food intake". Nature 382 (6587): 168–71. PMID 8700207. doi:10.1038/382168a0. 
  2. ^ Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (Feb 1998). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics 46 (2): 287–90. PMID 9417917. doi:10.1006/geno.1997.5024. 
  3. ^ "Entrez Gene: NPY5R neuropeptide Y receptor Y5". 
  4. ^ Kakui N, Tanaka J, Tabata Y, Asai K, Masuda N, Miyara T, Nakatani Y, Ohsawa F, Nishikawa N, Sugai M, Suzuki M, Aoki K, Kitaguchi H (May 2006). "Pharmacological characterization and feeding-suppressive property of FMS586 [3-(5,6,7,8-tetrahydro-9-isopropyl-carbazol-3-yl)-1-methyl-1-(2-pyridin-4-yl-ethyl)-urea hydrochloride], a novel, selective, and orally active antagonist for neuropeptide Y Y5 receptor". The Journal of Pharmacology and Experimental Therapeutics 317 (2): 562–70. PMID 16436501. doi:10.1124/jpet.105.099705. 
  5. ^ Walker MW, Wolinsky TD, Jubian V, Chandrasena G, Zhong H, Huang X, Miller S, Hegde LG, Marsteller DA, Marzabadi MR, Papp M, Overstreet DH, Gerald CP, Craig DA (March 2009). "The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 (N-([trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl)-methanesulfonamide) exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity". The Journal of Pharmacology and Experimental Therapeutics 328 (3): 900–11. PMID 19098165. doi:10.1124/jpet.108.144634. 
  6. ^ MacNeil DJ (2007). "NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs". Current Topics in Medicinal Chemistry 7 (17): 1721–33. PMID 17979781. doi:10.2174/156802607782341028. 
  7. ^ Islam I, Dhanoa D, Finn J, Du P, Walker MW, Salon JA, Zhang J, Gluchowski C (July 2002). "Discovery of potent and selective small molecule NPY Y5 receptor antagonists". Bioorganic & Medicinal Chemistry Letters 12 (13): 1767–9. PMID 12067557. doi:10.1016/S0960-894X(02)00287-1. 

External links

Further reading

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