Open Access Articles- Top Results for Neurotensin receptor 2

Neurotensin receptor 2

SymbolsNTSR2 ; NTR2
External IDsOMIM605538 MGI108018 HomoloGene7452 IUPHAR: 310 ChEMBL: 2514 GeneCards: NTSR2 Gene
RNA expression pattern
File:PBB GE NTSR2 206899 at tn.png
More reference expression data
RefSeq (mRNA)NM_012344NM_008747
RefSeq (protein)NP_036476NP_032773
Location (UCSC)Chr 2:
11.8 – 11.81 Mb
Chr 12:
16.65 – 16.66 Mb
PubMed search[1][2]

Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.[1][2][3]

The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.[3]

See also


  1. ^ Chalon P, Vita N, Kaghad M, Guillemot M, Bonnin J, Delpech B, Le Fur G, Ferrara P, Caput D (Jul 1996). "Molecular cloning of a levocabastine-sensitive neurotensin binding site". FEBS Lett 386 (2-3): 91–4. PMID 8647296. doi:10.1016/0014-5793(96)00397-3. 
  2. ^ Vita N, Oury-Donat F, Chalon P, Guillemot M, Kaghad M, Bachy A, Thurneyssen O, Garcia S, Poinot-Chazel C, Casellas P, Keane P, Le Fur G, Maffrand JP, Soubrie P, Caput D, Ferrara P (Feb 1999). "Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells". Eur J Pharmacol 360 (2-3): 265–72. PMID 9851594. doi:10.1016/S0014-2999(98)00678-5. 
  3. ^ a b "Entrez Gene: NTSR2 neurotensin receptor 2". 

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

External links

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