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Nifuratel

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Nifuratel
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Systematic (IUPAC) name
5-[(Methylthio)methyl]-3-{[(1E)-(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one
Clinical data
AHFS/Drugs.com International Drug Names
Identifiers
4936-47-4 7pxY
G01AX05
PubChem CID 6433427
ChemSpider 4938579
UNII U60U6P08SP 7pxY
KEGG D01050 7pxY
Chemical data
Formula C10H11N3O5S
285.28 g/mol
 14pxY (what is this?)  (verify)

Nifuratel (brand name Macmiror, or—in combination with nystatinMacmiror Complex) is a drug used in gynecology. It is a local antiprotozoal and antifungal agent that may also be given orally. Nifuratel is not approved for use in the United States.

Nifuratel appears to have a broad antibacterial spectrum of action and is effective against Chlamydia trachomatis and Mycoplasma spp. as well as fungal infections from Candida spp.[1]

Taken orally, or as a vaginal pessary, it is used in the treatment of a wide range of infections of the genito-urinary tract, especially if there is no accurate diagnosis available. For example it may be used in the treatment of women exhibiting vaginal discharge where there is uncertainty as to whether the cause is Trichomonas vaginalis or Candida strains such as Candida albicans.

Side effects appear to be minimal or non-existent and it has a safe toxicological profile.[2]

References

  1. ^ Treatment of candidal urinary tract infection with nifuratel. R N Grüneberg, A Leakey
  2. ^ Microbiological and pharmaco-toxicological profile of nifuratel and its favourable risk/benefit ratio for the treatment of vulvo-vaginal infections. A review. Werner Mendling, Federico Mailland Klinik für Frauenheilkunde und Geburtshilfe, Klinikum Am Urban, Berlin, Germany.