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Open Access Articles- Top Results for Niperotidine

Niperotidine

Niperotidine
280px
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IUPAC name
(Z)-N-(1,3-benzodioxol-5-ylmethyl)-N'-{2[({5-[(dimethylamino)methyl]-2-furyl}methyl)thio]ethyl}-2-nitroethylene-1,1-diamine
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ATC code A02BA05
84845-75-0 7pxY
ChEMBL ChEMBL1909284 7pxN
ChemSpider 11644617 7pxN
EC number 284-304-0
Jmol-3D images Image
KEGG D07072 7pxY
MeSH C073716
PubChem Template:Chembox PubChem/format
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C20H26N4O5S
Molar mass 434.50924
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Niperotidine is a histamine antagonist selective for the H2 subtype. It was trialled as a treatment for excessive gastric acidity,[1] but withdrawn after human trials showed liver damage.[2]

References

  1. ^ Palasciano G, Maggi V, Portincasa P. The effect of the H2-antagonist niperotidine on intragastric acidity in healthy subjects undergoing 24-hour pH-monitoring. Italian Journal of Gastroenterology. 1990 Oct;22(5):291-4. PMID 1983712
  2. ^ Gasbarrini G, Gentiloni N, Febbraro S, Gasbarrini A, Di Campli C, Cesana M, Miglio F, Miglioli M, Ghinelli F, D'Ambrosi A, Amoroso P, Pacini F, Salvadori G. Acute liver injury related to the use of niperotidine. Journal of Hepatology. 1997 Sep;27(3):583-6. PMID 9314138


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