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Norfenfluramine

Norfenfluramine
200px
Ball-and-stick model of the norfenfluramine molecule
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IUPAC name
1-[3-(Trifluoromethyl)phenyl]propan-2-amine
Other names
3-Trifluoromethylamphetamine
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19036-73-8 7pxY
ChemSpider 15108 7pxY
IUPHAR ligand 215
Jmol-3D images Image
PubChem Template:Chembox PubChem/format
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C10H12F3N
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Infobox references

Norfenfluramine, or 3-trifluoromethylamphetamine, is a drug of the amphetamine family which behaves as a serotonin and norepinephrine releasing agent and potent 5-HT2A, 5-HT2B, and 5-HT2C agonist. The action of norfenfluramine on 5-HT2B receptors on heart valves leads to a characteristic pattern of heart failure following proliferation of cardiac fibroblasts on the tricuspid valve, known as cardiac fibrosis.[1] This side effect led to the withdrawal of fenfluramine as an anorectic agent worldwide, and to the withdrawal of benfluorex in Europe,[2] as both fenfluramine and benfluorex form norfenfluramine as an active metabolite. It is a human TAAR1 agonist.[3]

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