Open Access Articles- Top Results for Noribogaine


Systematic (IUPAC) name
Clinical data
Metabolite of Iboga-alkaloid(s?) Ibogaine.
481-88-9 7pxN
PubChem CID 3083548
ChemSpider 2340735 7pxY
Chemical data
Formula C19H24N2O
296.407 g/mol
 14pxN (what is this?)  (verify)

Noribogaine, or 12-hydroxyibogamine, is the principal psychoactive metabolite of the psychedelic drug ibogaine. It is thought to be involved in the anti-addictive effects of ibogaine-containing plant extracts.[1][2][3]

A recent study evaluated its effects on healthy volunteers at doses of 3–60 mg, finding no tolerability issues.[4]

See also


  1. Glick SD, Maisonneuve IS (May 1998). "Mechanisms of antiaddictive actions of ibogaine". Annals of the New York Academy of Sciences 844: 214–26. PMID 9668680. doi:10.1111/j.1749-6632.1998.tb08237.x. 
  2. Baumann MH, Pablo J, Ali SF, Rothman RB, Mash DC (2001). "Comparative neuropharmacology of ibogaine and its O-desmethyl metabolite, noribogaine". The Alkaloids. Chemistry and Biology 56: 79–113. PMID 11705118. doi:10.1016/S0099-9598(01)56009-5. 
  3. Kubiliene A, Marksiene R, Kazlauskas S, Sadauskiene I, Razukas A, Ivanov L (2008). "Acute toxicity of ibogaine and noribogaine". Medicina (Kaunas, Lithuania) 44 (12): 984–8. PMID 19142057. 
  4. "Ascending-dose study of noribogaine in healthy volunteers: Pharmacokinetics, pharmacodynamics, safety, and tolerability.". The Journal of Clinical Pharmacology 55: 189–94. Oct 3, 2014. PMID 25279818. doi:10.1002/jcph.404. 


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