Normocytic anemia is a common issue that occurs for men and women typically over 85 years old. Its prevalence increases with age, reaching 44 percent in men older than 85 years.
The issue is thought of as representing any of the following:
- a decrease production of normal-sized red blood cells (e.g., anemia of chronic disease, aplastic anemia);
- an increased production of HbS as seen in sickle cell disease (not sickle cell trait);
- an increased destruction or loss of red blood cells (e.g., hemolysis, posthemorrhagic anemia);
- an uncompensated increase in plasma volume (e.g., pregnancy, fluid overload);
- a B2 (riboflavin) deficiency
- a B6 (pyridoxine) deficiency
- or a mixture of conditions producing microcytic and macrocytic anemia.
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