Open Access Articles- Top Results for OTX1


SymbolsOTX1 ; FLJ38361; MGC15736
External IDsOMIM600036 MGI97450 HomoloGene7875 GeneCards: OTX1 Gene
RefSeq (mRNA)NM_001199770NM_011023
RefSeq (protein)NP_001186699NP_035153
Location (UCSC)Chr 2:
63.28 – 63.28 Mb
Chr 11:
21.99 – 22 Mb
PubMed search[1][2]

Homeobox protein OTX1 is a protein that in humans is encoded by the OTX1 gene.[1][2]

This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. The Otx gene is active in the region of the first gill arch, which is related to the upper and lower jaw and two of the bones of the ear.[3] A similar protein in mice is required for proper brain and sensory organ development and can cause epilepsy.[2]


  1. ^ Kastury K, Druck T, Huebner K, Barletta C, Acampora D, Simeone A, Faiella A, Boncinelli E (Dec 1994). "Chromosome locations of human EMX and OTX genes". Genomics 22 (1): 41–5. PMID 7959790. doi:10.1006/geno.1994.1343. 
  2. ^ a b "Entrez Gene: OTX1 orthodenticle homeobox 1". 
  3. ^ Shubin, Neil "Your Inner Fish" 2009

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