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Oncostatin M receptor

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Identifiers
SymbolsOSMR ; OSMRB; PLCA1
External IDsOMIM601743 MGI1330819 HomoloGene2972 IUPHAR: 1714 GeneCards: OSMR Gene
Orthologs
SpeciesHumanMouse
Entrez918018414
EnsemblENSG00000145623ENSMUSG00000022146
UniProtQ99650O70458
RefSeq (mRNA)NM_001168355NM_011019
RefSeq (protein)NP_001161827NP_035149
Location (UCSC)Chr 5:
38.85 – 38.95 Mb
Chr 15:
6.81 – 6.87 Mb
PubMed search[1][2]

Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor, is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene.[1][2]

OSMR is a member of the type I cytokine receptor family. This protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events.[1]

Clinical significance

The oncostatin M receptor is associated with primary cutaneous amyloidosis.[3]

References

  1. ^ a b "Entrez Gene: oncostatin M receptor". 
  2. ^ Mosley B, De Imus C, Friend D, Boiani N, Thoma B, Park LS, Cosman D (December 1996). "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation". J. Biol. Chem. 271 (51): 32635–43. PMID 8999038. doi:10.1074/jbc.271.51.32635. 
  3. ^ Arita K, South AP, Hans-Filho G et al. (January 2008). "Oncostatin M Receptor-β Mutations Underlie Familial Primary Localized Cutaneous Amyloidosis". Am. J. Hum. Genet. 82 (1): 73–80. PMC 2253984. PMID 18179886. doi:10.1016/j.ajhg.2007.09.002. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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