Open Access Articles- Top Results for Org 21465

Org 21465

Org 21465
Systematic (IUPAC) name
Clinical data
PubChem CID 10697702
Chemical data
Formula C27H43NO7S
 14pxY (what is this?)  (verify)

Org 21465 is a synthetic neuroactive steroid, with sedative effects resulting from its action as a GABAA receptor positive allosteric modulator. It is similar to related drugs such as Org 20599, and was similarly developed as an improved alternative to other sedative steroids such as althesin and allopregnanolone, which despite its superior properties in some respects has not proved to offer enough advantages to be accepted into clinical use.[1][2]

See also


  1. ^ Sear JW. ORG 21465, a new water-soluble steroid hypnotic: more of the same or something different? British Journal of Anaesthsia. 1997 Oct;79(4):417-9. PMID 9389254
  2. ^ Vanlersberghe C, Camu F. Etomidate and other non-barbiturates. Handbook of Experimental Pharmacology. 2008;(182):267-82. PMID 18175096

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