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Open Access Articles- Top Results for Oroxylin A

Oroxylin A

Oroxylin A
Skeletal formula
Ball-and-stick model of oroxylin A
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This page is a soft redirect. Names

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IUPAC name
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one
Other names
Baicalein 6-methyl ether
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480-11-5 7pxY
ChEBI CHEBI:61668 7pxN
Jmol-3D images Image
PubChem Template:Chembox PubChem/format
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C16H12O5
Molar mass 284.26 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 14pxN verify (what is10pxY/10pxN?)
Infobox references

Oroxylin A is an O-methylated flavone, a chemical compound that can be found in the medicinal plant Scutellaria baicalensis[1] and the Oroxylum indicum tree.[2] It has demonstrated activity as a dopamine reuptake inhibitor,[3] and is also a negative allosteric modulator of the benzodiazepine site of the GABAA receptor.[4][3][5] Oroxylin A has been found to improve memory consolidation in mice by elevating brain-derived neurotrophic factor (BDNF) levels in the hippocampus.[6]

See also

References

  1. ^ Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography. Hua-Bin Li and Feng Chen, Journal of Chromatography A, 13 May 2005, Volume 1074, Issues 1–2, pages 107–110, doi:10.1016/j.chroma.2005.03.088
  2. ^ The constitution of oroxylin-A, a yellow colouring matter from the root-bark of Oroxylum indicum, vent R. C. Shah, C. R. Mehta and T. S. Wheeler
  3. ^ a b Yoon, Seo Young; dela Peña, Ike; Kim, Sung Mok; Woo, Tae Sun; Shin, Chan Young; Son, Kun Ho; Park, Haeil; Lee, Yong Soo; Ryu, Jong Hoon; Jin, Mingli; Kim, Kyeong-Man; Cheong, Jae Hoon (2013). "Oroxylin A improves attention deficit hyperactivity disorder-like behaviors in the spontaneously hypertensive rat and inhibits reuptake of dopamine in vitro". Archives of Pharmacal Research 36 (1): 134–140. ISSN 0253-6269. doi:10.1007/s12272-013-0009-6. 
  4. ^ Liao JF, Wang HH, Chen MC, Chen CC, Chen CF (1998). "Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root". Planta Med. 64 (6): 571–2. PMID 9776664. doi:10.1055/s-2006-957517. 
  5. ^ Liu X, Hong SI, Park SJ, Dela Peña JB, Che H, Yoon SY et al. (2013). "The ameliorating effects of 5,7-dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one, an oroxylin A derivative, against memory impairment and sensorimotor gating deficit in mice". Arch. Pharm. Res. 36 (7): 854–63. PMID 23543630. doi:10.1007/s12272-013-0106-6. 
  6. ^ Kim DH, Lee Y, Lee HE, Park SJ, Jeon SJ, Jeon SJ et al. (2014). "Oroxylin A enhances memory consolidation through the brain-derived neurotrophic factor in mice". Brain Res. Bull. 108: 67–73. PMID 25218897. doi:10.1016/j.brainresbull.2014.09.001. 


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