13 January 1858|
Aleksotas, Russian Empire (now Lithuania)
18 July 1931|
|Institutions||University of Breslau|
|Doctoral advisor||Template:If empty|
|Known for||pancreas and diabetes|
|Influences||Josef von Mering|
Oskar Minkowski (13 January 1858 – 18 July 1931) held a professorship at the University of Breslau and is most famous for his research on diabetes. He was the brother of the mathematician Hermann Minkowski and father of astrophysicist Rudolph Minkowski.
Life and career
Born in Aleksotas, of Jewish origin, Minkowski was the son of Rachel (née Taubmann) and Lewin Boruch Minkowski (1825–1884), a first-guild merchant, who subsidized construction of The Choral synagogue in Kovno.
Discovery of the role of pancreas in diabetes
Minkowski worked with Josef von Mering on the study of diabetes at the University of Strasbourg. Their landmark study in 1889 in dogs induced diabetes by removing their pancreas. It was Minkowski who performed the operation and made the crucial link to recognize that the symptoms of the treated dogs were due to diabetes. Thus they were able to indicate that the pancreas contained regulators to control blood sugar; they also provided a model for the study of diabetes. Their work led other doctors and scientists to pursue further research on the relation of the pancreas to diabetes, and ultimately resulted in the discovery of insulin as a treatment for the disease.
- Joseph von Mering, Oskar Minkowski: Diabetes mellitus nach Pankreasextirpation. Centralblatt für klinische Medicin, Leipzig, 1889, 10 (23): 393–394. Archiv für experimentelle Patholgie und Pharmakologie, Leipzig, 1890, 26: 37. It begins with, After removal of the pancreas dogs get diabetes. It starts sometime after the operation and will persist for weeks continuously until their death...
In recognition of the discovery by Minkowski the European Association for the Study of Diabetes annually awards the Minkowski Prize for outstanding original work of a younger investigator in diabetes research.
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