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Oxaprozin

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Oxaprozin
File:Oxaprozin.svg
Systematic (IUPAC) name
3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid
Clinical data
Trade names Daypro
AHFS/Drugs.com monograph
MedlinePlus a693002
  • C
Oral
Pharmacokinetic data
Bioavailability 95%
Protein binding 99%
Metabolism Liver—65% oxidation and 35% glucuronic acid conjugation. 5% are active phenolic metabolites.
Half-life 54.9 hours
Identifiers
21256-18-8 7pxY
M01AE12
PubChem CID 4614
DrugBank DB00991 7pxY
ChemSpider 4453 7pxY
UNII MHJ80W9LRB 7pxY
KEGG D00463 7pxY
ChEBI CHEBI:7822 7pxN
ChEMBL CHEMBL1071 7pxY
Chemical data
Formula C18H15NO3
293.317 g/mol
 14pxN (what is this?)  (verify)

Oxaprozin, also known as Oxaprozinum, (sold under the names: Daypro, Dayrun, Duraprox) is a non-steroidal anti-inflammatory drug (NSAID),[1] used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. Chemically, it is a propionic acid derivative. It is available in 600 mg tablets. Normal adult dosage is 1200 mg daily, not to exceed 1800 mg per day. Safety and efficacy has been established in children over 6 years with juvenile rheumatoid arthritis only, and there is an increased risk of adverse reactions in the elderly population.

References

  1. ^ Greenblatt DJ, Matlis R, Scavone JM, Blyden GT, Harmatz JS, Shader RI (March 1985). "Oxaprozin pharmacokinetics in the elderly". British Journal of Clinical Pharmacology 19 (3): 373–8. PMC 1463728. PMID 3986088. doi:10.1111/j.1365-2125.1985.tb02656.x. 


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