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Open Access Articles- Top Results for Oxyfedrine

Oxyfedrine

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Oxyfedrine
File:Oxyfedrine2.png
Systematic (IUPAC) name
(RS)-3-[(2-Hydroxy-1-methyl-2-phenylethyl)amino]-1-(3-methoxyphenyl)propan-1-one
Clinical data
AHFS/Drugs.com International Drug Names
Identifiers
15687-41-9 7pxY
C01DX03
PubChem CID 27454
UNII DWL616XF1K 7pxY
KEGG D08321 7pxY
Chemical data
Formula C19H23NO3
313.39 g/mol
 14pxY (what is this?)  (verify)

Oxyfedrine is a vasodilator. Oxyfedrine was found to depress the tonicity of coronary vessels, improve myocardial metabolism (so that heart can sustain hypoxia better) and also exert a positive chronotropic and inotrophic effects, thereby not precipitating angina pectoris. The latter property (positive chronotropic and inotrophic effects) is particularly important, because other vasodilators used in angina may be counter productive causing coronary steal phenomenon.

Synergestic effects with antibiotics have been suggested.[1]

References

  1. ^ Mazumdar K, Dutta NK, Kumar KA, Dastidar SG; Kumar (April 2005). "In vitro and in vivo synergism between tetracycline and the cardiovascular agent oxyfedrine HCl against common bacterial strains" ([DEAD LINK]). Biol. Pharm. Bull. 28 (4): 713–7. PMID 15802815. doi:10.1248/bpb.28.713.  Missing |last2= in Authors list (help)


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