Adverts

Open Access Articles- Top Results for P-selectin glycoprotein ligand-1

P-selectin glycoprotein ligand-1

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsSELPLG ; CD162; CLA; PSGL-1; PSGL1
External IDsOMIM600738 MGI106689 HomoloGene2261 ChEMBL: 4183 GeneCards: SELPLG Gene
RNA expression pattern
File:PBB GE SELPLG 209879 at tn.png
File:PBB GE SELPLG 209880 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez640420345
EnsemblENSG00000110876ENSMUSG00000048163
UniProtQ14242n/a
RefSeq (mRNA)NM_001206609NM_009151
RefSeq (protein)NP_001193538NP_033177
Location (UCSC)Chr 12:
109.02 – 109.03 Mb
Chr 5:
113.82 – 113.83 Mb
PubMed search[1][2]

Selectin P ligand, also known as SELPLG or CD162 (cluster of differentiation 162), is a human gene.

SELPLG is the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. The organization of the SELPG gene closely resembles that of CD43 and the human platelet glycoprotein GpIb-alpha both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters.[1]

P-selectin glycoprotein ligand-1 is a glycoprotein found on white blood cells and endothelial cells that binds to P-selectin (P stands for platelet), which is one of a family of selectins that includes E-selectin (endothelial) and L-selectin (leukocyte). Selectins are part of the broader family of cell adhesion molecules. PSGL-1 can bind to all three members of the family but binds best (with the highest affinity) to P-selectin.

Posttranslational modification

PSGL-1 protein requires two distinct posttranslational modifications to gain its selectin binding activity:

Function

PSGL-1 is expressed on all white blood cells and plays an important role in the recruitment of white blood cells into inflamed tissue.

White blood cells normally do not interact with the endothelium of blood vessels. However, inflammation causes the expression of cell adhesion molecules (CAM) such as P-selectin on the surface of the blood vessel wall. White blood cells present in flowing blood can interact with CAM. The first step in this interaction process is carried out by PSGL-1 interacting with P-selectin and/or E-selectin on endothelial cells and adherent platelets. This interaction results in "rolling" of the white blood cell on the endothelial cell surface followed by stable adhesion and transmigration of the white blood cell into the inflamed tissue.

References

Further reading

</dl>

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Lua error in package.lua at line 80: module 'Module:Buffer' not found. Lua error in package.lua at line 80: module 'Module:Buffer' not found.