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P2RY1

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Identifiers
SymbolsP2RY1 ; P2Y1
External IDsOMIM601167 MGI105049 HomoloGene1926 IUPHAR: 323 ChEMBL: 4315 GeneCards: P2RY1 Gene
RNA expression pattern
File:PBB GE P2RY1 207455 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez502818441
EnsemblENSG00000169860ENSMUSG00000027765
UniProtP47900P49650
RefSeq (mRNA)NM_002563NM_001282016
RefSeq (protein)NP_002554NP_001268945
Location (UCSC)Chr 3:
152.55 – 152.56 Mb
Chr 3:
61 – 61.01 Mb
PubMed search[1][2]

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.[1]

The product of this gene, P2Y1 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.[2]

See also

References

  1. ^ Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP (Mar 1996). "Cloning and chromosomal localization of the human P2Y1 purinoceptor". Biochem Biophys Res Commun 218 (3): 783–788. PMID 8579591. doi:10.1006/bbrc.1996.0139. 
  2. ^ "Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1". 

External links

  • "P2Y Receptors: P2Y1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

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