Open Access Articles- Top Results for P2RY8


SymbolsP2RY8 ; P2Y8
External IDsOMIM300525 HomoloGene65345 IUPHAR: 164 GeneCards: P2RY8 Gene
RNA expression pattern
File:PBB GE P2RY8 gnf1h10171 at tn.png
File:PBB GE P2RY8 gnf1h10172 s at tn.png
More reference expression data
RefSeq (mRNA)NM_178129n/a
RefSeq (protein)NP_835230n/a
Location (UCSC)Chr X:
1.46 – 1.54 Mb
PubMed search[1]n/a

P2Y purinoceptor 8 is a protein that in humans is encoded by the P2RY8 gene.[1][2]

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y.[2]

Clinical relevance

Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[3]

See also


  1. ^ Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (Sep 2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochim Biophys Acta 1492 (1): 127–38. PMID 11004484. doi:10.1016/S0167-4781(00)00094-4. 
  2. ^ a b "Entrez Gene: P2RY8 purinergic receptor P2Y, G-protein coupled, 8". 
  3. ^ Lohr, JG; Stojanov, P, Lawrence, MS, Auclair, D, Chapuy, B, Sougnez, C, Cruz-Gordillo, P, Knoechel, B, Asmann, YW, Slager, SL, Novak, AJ, Dogan, A, Ansell, SM, Link, BK, Zou, L, Gould, J, Saksena, G, Stransky, N, Rangel-Escareño, C, Fernandez-Lopez, JC, Hidalgo-Miranda, A, Melendez-Zajgla, J, Hernández-Lemus, E, Schwarz-Cruz Y Celis, A, Imaz-Rosshandler, I, Ojesina, AI, Jung, J, Pedamallu, CS, Lander, ES, Habermann, TM, Cerhan, JR, Shipp, MA, Getz, G, Golub, TR (Feb 17, 2012). "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing.". Proceedings of the National Academy of Sciences of the United States of America 109 (10): 3879–84. PMC 3309757. PMID 22343534. doi:10.1073/pnas.1121343109. 

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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