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Open Access Articles- Top Results for PF-03550096

PF-03550096

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PF-03550096
File:PF-03550096 structure.png
Systematic (IUPAC) name
N-[(1S)-1-(aminocarbonyl)-2,2-dimethylpropyl]-2,3-dihydro-3-(3-hydroxy-3-methylbutyl)-2-oxo-1H-benzimidazole-1-carboxamide
Clinical data
Identifiers
910376-39-5 7pxY
PubChem CID 24857887
ChemSpider 21378519
Chemical data
Formula C19H28N4O4
376.45 g/mol

PF-03550096 is a drug that acts as a potent agonist for the CB2 cannabinoid receptor, with good selectivity over CB1 having Ki values of 7nM at CB2 and 1500nM at CB1. It was originally developed by Pfizer in 2008 as a medication for irritable bowel syndrome,[1] but has only progressed to animal studies.[2]

See also

References

  1. ^ Ando K et al, BENZIMIDAZOLONE DERIVATIVES. WO 2008/032164
  2. ^ Kikuchi, A.; Ohashi, K.; Sugie, Y.; Sugimoto, H.; Omura, H. (2008). "Pharmacological evaluation of a novel cannabinoid 2 (CB2) ligand, PF-03550096, in vitro and in vivo by using a rat model of visceral hypersensitivity". Journal of pharmacological sciences 106 (2): 219–224. PMID 18270474. doi:10.1254/jphs.FP0071599.  edit


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