Open Access Articles- Top Results for PHF17


SymbolsJADE1 ; PHF17
External IDsOMIM610514 MGI1925835 HomoloGene18162 GeneCards: JADE1 Gene
RNA expression pattern
File:PBB GE PHF17 218517 at tn.png
File:PBB GE PHF17 gnf1h01443 s at tn.png
File:PBB GE PHF17 gnf1h09361 s at tn.png
More reference expression data
RefSeq (mRNA)NM_001287437NM_001130184
RefSeq (protein)NP_001274366NP_001123656
Location (UCSC)Chr 4:
129.73 – 129.8 Mb
Chr 3:
41.56 – 41.62 Mb
PubMed search[1][2]

Protein Jade-1 is a protein that in humans is encoded by the PHF17 gene.[1][2][3]


PHF17 has been shown to interact with Beta-catenin[4] and Von Hippel-Lindau tumor suppressor.[2]


  1. ^ Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (May 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 8 (2): 85–95. PMID 11347906. doi:10.1093/dnares/8.2.85. 
  2. ^ a b Zhou MI, Wang H, Ross JJ, Kuzmin I, Xu C, Cohen HT (Oct 2002). "The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1". J Biol Chem 277 (42): 39887–98. PMID 12169691. doi:10.1074/jbc.M205040200. 
  3. ^ "Entrez Gene: PHF17 PHD finger protein 17". 
  4. ^ Chitalia, Vipul C; Foy Rebecca L, Bachschmid Markus M, Zeng Liling, Panchenko Maria V, Zhou Mina I, Bharti Ajit, Seldin David C, Lecker Stewart H, Dominguez Isabel, Cohen Herbert T (Oct 2008). "Jade-1 inhibits Wnt signaling by ubiquitinating β-catenin and mediates Wnt pathway inhibition by pVHL". Nat. Cell Biol. (England) 10 (10): 1208–16. PMC 2830866. PMID 18806787. doi:10.1038/ncb1781. 

Further reading


External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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