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Open Access Articles- Top Results for PKN3 (gene)

PKN3 (gene)

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Identifiers
SymbolsPKN3 ; RP11-545E17.1
External IDsOMIM610714 MGI2388285 HomoloGene50980 IUPHAR: 1522 GeneCards: PKN3 Gene
EC number2.7.11.13
RNA expression pattern
File:PBB GE PKN3 gnf1h00136 at tn.png
File:PBB GE PKN3 gnf1h00137 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez29941263803
EnsemblENSG00000160447ENSMUSG00000026785
UniProtQ6P5Z2Q8K045
RefSeq (mRNA)NM_013355NM_153805
RefSeq (protein)NP_037487NP_722500
Location (UCSC)Chr 9:
131.46 – 131.48 Mb
Chr 2:
30.08 – 30.09 Mb
PubMed search[1][2]

PKN3 is a protein kinase C-related molecule and thought to be an effector mediating malignant cell growth downstream of activated phosphoinositide 3-kinase (PI3K).[1] It is thought that chronic activation of the phosphoinositide 3-kinase (PI3K)/PTEN signal transduction pathway contributes to metastatic cell growth and that PKN3 may mediate that growth.1

PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 may represent a target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.

Interactions

PKN3 (gene) has been shown to interact with ARHGAP26.[2]

References

  1. ^ "Entrez Gene: PKN3 protein kinase N3". 
  2. ^ Shibata, H; Oishi K; Yamagiwa A; Matsumoto M; Mukai H; Ono Y (Jul 2001). "PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family". J. Biochem. (Japan) 130 (1): 23–31. ISSN 0021-924X. PMID 11432776. doi:10.1093/oxfordjournals.jbchem.a002958. 

Further reading

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