Open Access Articles- Top Results for PLK3


SymbolsPLK3 ; CNK; FNK; PRK
External IDsOMIM602913 MGI109604 HomoloGene20865 IUPHAR: 2170 ChEMBL: 4897 GeneCards: PLK3 Gene
EC number2.7.11.21
RNA expression pattern
File:PBB GE PLK3 204958 at tn.png
File:PBB GE PLK3 215462 at tn.png
More reference expression data
RefSeq (mRNA)NM_004073NM_013807
RefSeq (protein)NP_004064NP_038835
Location (UCSC)Chr 1:
45.27 – 45.27 Mb
Chr 4:
117.13 – 117.13 Mb
PubMed search[1][2]

Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene.[1][2]


Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.[1]


PLK3 has been shown to interact with:


  1. ^ a b "Entrez Gene: PLK3 polo-like kinase 3 (Drosophila)". 
  2. ^ Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R et al. (August 1996). "Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas". J. Biol. Chem. 271 (32): 19402–8. PMID 8702627. doi:10.1074/jbc.271.32.19402. 
  3. ^ Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (Oct 1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene 18 (44): 6029–36. PMID 10557092. doi:10.1038/sj.onc.1202983. 
  4. ^ a b Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y et al. (Sep 2002). "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways". Oncogene 21 (43): 6633–40. PMID 12242661. doi:10.1038/sj.onc.1205850. 
  5. ^ Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C et al. (Nov 2001). "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway". J. Biol. Chem. 276 (46): 43305–12. PMID 11551930. doi:10.1074/jbc.M106050200. 

Further reading


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