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Open Access Articles- Top Results for PNU-142633

PNU-142633

PNU-142633
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IUPAC name
(S)-1-(2-(4-(4-Carbamoylphenyl)piperazin-1-yl)ethyl)-N-methylisochroman-6-carboxamide
Other names
PNU-142633F
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187665-65-2 7pxY
249765-69-3 (maleate) 7pxY
ChemSpider 8020862
Jmol-3D images Image
PubChem Template:Chembox PubChem/format
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C24H30N4O3
Molar mass Lua error in Module:Math at line 495: attempt to index field 'ParserFunctions' (a nil value). g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

PNU-142633 is an experimental drug candidate for the treatment of migraine. It exerts its effect as a selective, high affinity 5-HT1D receptor antagonist.[1][2] PNU-142633 is well tolerated after oral administration.[3]

References

  1. ^ Pregenzer, JF; Alberts, GL; Im, WB; Slightom, JL; Ennis, MD; Hoffman, RL; Ghazal, NB; Tenbrink, RE (1999). "Differential pharmacology between the guinea-pig and the gorilla 5-HT1D receptor as probed with isochromans (5-HT1D-selective ligands)". British journal of pharmacology 127 (2): 468–72. PMC 1566017. PMID 10385247. doi:10.1038/sj.bjp.0702532. 
  2. ^ PNU 142633, Santa Cruz Biotechnology
  3. ^ Fleishaker, JC; Pearson, LK; Knuth, DW; Gomez-Mancilla, B; Francom, SF; McIntosh, MJ; Freestone, S; Azie, NE (1999). "Pharmacokinetics and tolerability of a novel 5-HT1D agonist, PNU-142633F". International journal of clinical pharmacology and therapeutics 37 (10): 487–92. PMID 10543315. 



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