Adverts

Open Access Articles- Top Results for PRKAA2

PRKAA2

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsPRKAA2 ; AMPK; AMPK2; AMPKa2; PRKAA
External IDsOMIM600497 MGI1336173 HomoloGene4551 IUPHAR: 1542 ChEMBL: 2116 GeneCards: PRKAA2 Gene
EC number2.7.11.1, 2.7.11.27, 2.7.11.31
RNA expression pattern
File:PBB GE PRKAA2 207709 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez5563108079
EnsemblENSG00000162409ENSMUSG00000028518
UniProtP54646Q8BRK8
RefSeq (mRNA)NM_006252NM_178143
RefSeq (protein)NP_006243NP_835279
Location (UCSC)Chr 1:
57.11 – 57.18 Mb
Chr 4:
105.03 – 105.11 Mb
PubMed search[1][2]

5'-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded by the PRKAA2 gene.[1][2]

Function

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.[2]

References

  1. ^ Aguan K, Scott J, See CG, Sarkar NH (Dec 1994). "Characterization and chromosomal localization of the human homologue of a rat AMP-activated protein kinase-encoding gene: a major regulator of lipid metabolism in mammals". Gene 149 (2): 345–50. PMID 7959015. doi:10.1016/0378-1119(94)90174-0. 
  2. ^ a b "Entrez Gene: PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit". 

Further reading

</dl>

Lua error in package.lua at line 80: module 'Module:Buffer' not found.