Open Access Articles- Top Results for PRKCI


SymbolsPRKCI ; DXS1179E; PKCI; nPKC-iota
External IDsOMIM600539 MGI99260 HomoloGene37667 IUPHAR: 1490 ChEMBL: 2598 GeneCards: PRKCI Gene
EC number2.7.11.13
RNA expression pattern
File:PBB GE PRKCI 209678 s at tn.png
File:PBB GE PRKCI 209677 at tn.png
File:PBB GE PRKCI 213518 at tn.png
More reference expression data
RefSeq (mRNA)NM_002740NM_008857
RefSeq (protein)NP_002731NP_032883
Location (UCSC)Chr 3:
169.94 – 170.02 Mb
Chr 3:
31 – 31.05 Mb
PubMed search[1][2]

Protein kinase C iota type is an enzyme that in humans is encoded by the PRKCI gene.[1][2][3]

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.[3]


PRKCI has been shown to interact with Glyceraldehyde 3-phosphate dehydrogenase,[4] Centaurin, alpha 1,[5] Phosphoinositide-dependent kinase-1,[6] FRS2,[7] SMG1 (gene),[8] Sequestosome 1 and PARD3.[9][10]


  1. ^ Mazzarella R, Ciccodicola A, Esposito T, Arcucci A, Migliaccio C, Jones C, Schlessinger D, D'Urso M, D'Esposito M (August 1995). "Human protein kinase C Iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3". Genomics 26 (3): 629–31. PMID 7607695. doi:10.1016/0888-7543(95)80190-W. 
  2. ^ De Donato M, Gallagher DS Jr, Davis SK, Stelly DM, Taylor JF (April 2002). "The assignment of PRKCI to bovine chromosome 1q34-->q36 by FISH suggests a new assignment to human chromosome 3". Cytogenet Cell Genet 95 (1–2): 79–81. PMID 11978974. doi:10.1159/000057021. 
  3. ^ a b "Entrez Gene: PRKCI protein kinase C, iota". 
  4. ^ Tisdale EJ (February 2002). "Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota /lambda and plays a role in microtubule dynamics in the early secretory pathway". The Journal of Biological Chemistry 277 (5): 3334–41. PMID 11724794. doi:10.1074/jbc.M109744200. 
  5. ^ Zemlickova E, Dubois T, Kerai P et al. (August 2003). "Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C". Biochemical and Biophysical Research Communications 307 (3): 459–65. PMID 12893243. doi:10.1016/S0006-291X(03)01187-2. 
  6. ^ Balendran A, Biondi RM, Cheung PC, Casamayor A, Deak M, Alessi DR (July 2000). "A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1". The Journal of Biological Chemistry 275 (27): 20806–13. PMID 10764742. doi:10.1074/jbc.M000421200. 
  7. ^ Lim YP, Low BC, Lim J, Wong ES, Guy GR (July 1999). "Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling". The Journal of Biological Chemistry 274 (27): 19025–34. PMID 10383403. doi:10.1074/jbc.274.27.19025. 
  8. ^ Diaz-Meco MT, Municio MM, Sanchez P, Lozano J, Moscat J (1 January 1996). "Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo". Molecular and Cellular Biology 16 (1): 105–14. PMC 230983. PMID 8524286. 
  9. ^ Sanchez P, De Carcer G, Sandoval IV, Moscat J, Diaz-Meco MT (1 May 1998). "Localization of Atypical Protein Kinase C Isoforms into Lysosome-Targeted Endosomes through Interaction with p62". Molecular and Cellular Biology 18 (5): 3069–80. PMC 110686. PMID 9566925. 
  10. ^ Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (December 2002). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochemical and Biophysical Research Communications 299 (4): 641–6. PMID 12459187. doi:10.1016/S0006-291X(02)02698-0. 

Further reading


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