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Open Access Articles- Top Results for PRKD2

PRKD2

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Identifiers
SymbolsPRKD2 ; PKD2; nPKC-D2
External IDsOMIM607074 MGI2141917 HomoloGene9516 IUPHAR: 2173 ChEMBL: 4900 GeneCards: PRKD2 Gene
EC number2.7.11.13
RNA expression pattern
File:PBB GE PRKD2 209282 at tn.png
File:PBB GE PRKD2 38269 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez25865101540
EnsemblENSG00000105287ENSMUSG00000041187
UniProtQ9BZL6Q8BZ03
RefSeq (mRNA)NM_001079880NM_001252458
RefSeq (protein)NP_001073349NP_001239387
Location (UCSC)Chr 19:
47.18 – 47.22 Mb
Chr 7:
16.84 – 16.87 Mb
PubMed search[1][2]

Serine/threonine-protein kinase D2 or protein kinase C δ2 (PKC-δ2) is an enzyme that in humans is encoded by the PRKD2 gene.[1][2][3]

Function

The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases, a subfamily of protein kinase c. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms.[3]

References

  1. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res 10 (10): 1546–60. PMC 310934. PMID 11042152. doi:10.1101/gr.140200. 
  2. ^ Sturany S, Van Lint J, Muller F, Wilda M, Hameister H, Hocker M, Brey A, Gern U, Vandenheede J, Gress T, Adler G, Seufferlein T (May 2001). "Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases". J Biol Chem 276 (5): 3310–8. PMID 11062248. doi:10.1074/jbc.M008719200. 
  3. ^ a b "Entrez Gene: PRKD2 protein kinase D2". 

Further reading

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