Open Access Articles- Top Results for PTK6


SymbolsPTK6 ; BRK
External IDsOMIM602004 MGI99683 HomoloGene68494 IUPHAR: 2182 ChEMBL: 4601 GeneCards: PTK6 Gene
EC number2.7.10.2
RNA expression pattern
File:PBB GE PTK6 206482 at tn.png
More reference expression data
RefSeq (mRNA)NM_001256358NM_009184
RefSeq (protein)NP_001243287NP_033210
Location (UCSC)Chr 20:
62.16 – 62.17 Mb
Chr 2:
181.19 – 181.2 Mb
PubMed search[1][2]

Tyrosine-protein kinase 6 is an enzyme that in humans is encoded by the PTK6 gene.[1][2][3]


Tyrosine-protein kinase 6 (also known as Breast Tumor Kinase, Brk) is a cytoplasmic non-receptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. The encoded protein has been shown to undergo autophosphorylation.[3]

Clinical significance

Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue.[3]


PTK6 has been shown to interact with STAP2[4] and KHDRBS1.[5]


  1. ^ Lee ST, Strunk KM, Spritz RA (December 1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". Oncogene 8 (12): 3403–10. PMID 8247543. 
  2. ^ Park SH, Lee KH, Kim H, Lee ST (September 1997). "Assignment of the human PTK6 gene encoding a non-receptor protein tyrosine kinase to 20q13.3 by fluorescence in situ hybridization". Cytogenet Cell Genet 77 (3–4): 271–2. PMID 9284935. doi:10.1159/000134595. 
  3. ^ a b c "Entrez Gene: PTK6 PTK6 protein tyrosine kinase 6". 
  4. ^ Mitchell, P J; Sara E A; Crompton M R (August 2000). "A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK". Oncogene (ENGLAND) 19 (37): 4273–82. ISSN 0950-9232. PMID 10980601. doi:10.1038/sj.onc.1203775. 
  5. ^ Derry, J J; Richard S; Valderrama Carvajal H; Ye X; Vasioukhin V; Cochrane A W; Chen T; Tyner A L (August 2000). "Sik (BRK) Phosphorylates Sam68 in the Nucleus and Negatively Regulates Its RNA Binding Ability". Mol. Cell. Biol. (UNITED STATES) 20 (16): 6114–26. ISSN 0270-7306. PMC 86087. PMID 10913193. doi:10.1128/MCB.20.16.6114-6126.2000. 

Further reading