Open Access Articles- Top Results for Periplakin


SymbolsPPL ; KIAA0568; MGC134872
External IDsOMIM602871 MGI1194898 HomoloGene2026 GeneCards: PPL Gene
RNA expression pattern
File:PBB GE PPL 203407 at tn.png
More reference expression data
RefSeq (mRNA)NM_002705NM_008909
RefSeq (protein)NP_002696NP_032935
Location (UCSC)Chr 16:
4.93 – 5.01 Mb
Chr 16:
5.09 – 5.13 Mb
PubMed search[1][2]

Periplakin is a protein that in humans is encoded by the PPL gene.[1][2][3]

The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.[3]


PPL (gene) has been shown to interact with Keratin 8[4] and Envoplakin.[5][6]

See also


  1. ^ Ruhrberg C, Williamson JA, Maatta A, Watt FM (Jun 1998). "The periplakin gene maps to 16p13.3 in human and 16A-B1 in mouse". Genomics 49 (1): 157–9. PMID 9570964. doi:10.1006/geno.1997.5206. 
  2. ^ Aho S, McLean WH, Li K, Uitto J (Jun 1998). "cDNA cloning, mRNA expression, and chromosomal mapping of human and mouse periplakin genes". Genomics 48 (2): 242–7. PMID 9521878. doi:10.1006/geno.1997.5188. 
  3. ^ a b "Entrez Gene: PPL periplakin". 
  4. ^ Kazerounian, Shideh; Uitto Jouni; Aho Sirpa (Oct 2002). "Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin". Exp. Dermatol. (Denmark) 11 (5): 428–38. ISSN 0906-6705. PMID 12366696. doi:10.1034/j.1600-0625.2002.110506.x. 
  5. ^ Karashima, Tadashi; Watt Fiona M (Dec 2002). "Interaction of periplakin and envoplakin with intermediate filaments". J. Cell. Sci. (England) 115 (Pt 24): 5027–37. ISSN 0021-9533. PMID 12432088. doi:10.1242/jcs.00191. 
  6. ^ Ruhrberg, C; Hajibagheri M A; Parry D A; Watt F M (Dec 1997). "Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin". J. Cell Biol. (UNITED STATES) 139 (7): 1835–49. ISSN 0021-9525. PMC 2132639. PMID 9412476. doi:10.1083/jcb.139.7.1835. 

Further reading