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Pheniprazine

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Pheniprazine
200px
Systematic (IUPAC) name
(1-methyl-2-phenyl-ethyl)hydrazine
Clinical data
  • Uncontrolled
Oral
Identifiers
55-52-7 7pxN
None
PubChem CID 5929
ChemSpider 5716 7pxY
UNII 37VKD7067M 7pxY
ChEMBL CHEMBL22498 7pxY
Chemical data
Formula C9H14N2
150.22 g/mol
 14pxN (what is this?)  (verify)

Pheniprazine (Catron, Cavodil) is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant in the 1960s.[1][2][3] It was also used in the treatment of angina pectoris and schizophrenia.[4][5] Pheniprazine has been largely discontinued due to toxicity concerns such as jaundice, amblyopia, and optic neuritis.[6][7][8]

See also

References

  1. ^ LEAR TE, BROWNE MW, GREEVES JA (November 1962). "A controlled trial of cavodil (pheniprazine) in depression". J Ment Sci 108: 856–58. PMID 13928843. 
  2. ^ Fagervall I, Ross SB (April 1986). "Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors". Biochemical pharmacology 35 (8): 1381–7. PMID 2870717. doi:10.1016/0006-2952(86)90285-6. 
  3. ^ EBERSON LE, PERSSON K (July 1962). "Studies on Monoamine Oxidase Inhibitors. 1. The Autoxidation of beta-Phenylisopropylhydrazine as a Model Reaction for Irreversible Monoamine Oxidase Inhibition.". J Med Pharm Chem 91: 738–52. PMID 14056405. 
  4. ^ SANDLER G (March 1961). "Clinical evaluation of pheniprazine in angina pectoris". Br Med J 1 (5228): 792–4. PMC 1953879. PMID 13746179. doi:10.1136/bmj.1.5228.792. 
  5. ^ WICKSTROM L, HAHN N (September 1962). "[beta-Phenylisoprophlhydrazine (Catran) in schizophrenia.]". Nord Med (in Swedish) 68: 1165–7. PMID 14000469. 
  6. ^ FENTEM PH, HOWITT G (December 1961). "Fatal jaundice after administration of pheniprazine". Br Med J 2 (5267): 1616–7. PMC 1970739. PMID 13892290. doi:10.1136/bmj.2.5267.1616. 
  7. ^ FRANDSEN E (1962). "Toxic amblyopia during antidepressant treatment with pheniprazine (Catran)". Acta Psychiatr Scand 38: 1–14. PMID 13894598. doi:10.1111/j.1600-0447.1962.tb01780.x. 
  8. ^ THOMSEN NJ (January 1963). "[Optic neuritis after treatment with Catran.]". Ugeskr. Laeg. (in Danish) 125: 138–9. PMID 13981222. 

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