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Phenprobamate

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Phenprobamate
200px
Systematic (IUPAC) name
3-Phenylpropylcarbamate
Clinical data
AHFS/Drugs.com International Drug Names
Pharmacokinetic data
Half-life 5 - 8 hours
Identifiers
673-31-4 7pxN
M03BA01
PubChem CID 4770
ChemSpider 4606 7pxY
UNII UJZ473TPS0 7pxY
KEGG D01824 7pxY
ChEMBL CHEMBL1079576 7pxY
Chemical data
Formula C10H13NO2
179.22
 14pxN (what is this?)  (verify)

Phenprobamate (Gamaquil, Isotonil) is a centrally acting skeletal muscle relaxant, with additional sedative and anticonvulsant effects. Overdose is similar to barbiturates. Its mechanism of action is probably similar to meprobamate. Phenprobamate was previously used in humans as an anxiolytic, and is still sometimes used in general anesthesia and for treating muscle cramps and spasticity. Phenprobamate is still used in some European countries, but it has generally been replaced by newer drugs. Phenprobamate is metabolized by oxidative degradation of the carbamate group and ortho-hydroxylation of the benzene ring, and is eliminated in urine by the kidneys.

Doses range from 400 to 800 mg, up to 3 times a day.

References


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