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Phosphoribosyl pyrophosphate

"PRPP" redirects here. It is not to be confused with Pooled Retirement Pension Plan.
Phosphoribosyl pyrophosphate
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7540-64-9 7pxN
ChEBI CHEBI:17111 7pxY
ChemSpider 7062 7pxY
DrugBank DB01632 7pxY
Jmol-3D images Image
MeSH Phosphoribosyl+pyrophosphate
PubChem Template:Chembox PubChem/format
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C5H13O14P3
Molar mass 390.07 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Phosphoribosyl pyrophosphate (PRPP) is a pentosephosphate.

It is formed from ribose 5-phosphate by the enzyme ribose-phosphate diphosphokinase.

It plays a role in transferring phospho-ribose groups in several reactions:

Enzyme Reactant Product
adenine phosphoribosyltransferase adenine AMP
hypoxanthine-guanine phosphoribosyltransferase guanine GMP
hypoxanthine-guanine phosphoribosyltransferase hypoxanthine IMP
orotate phosphoribosyltransferase orotate OMP
uracil phosphoribosyltransferase uracil UMP

In de novo generation of purines, the enzyme amidophosphoribosyltransferase acts upon PRPP to create phosphoribosylamine.

Increased PRPP

Increased levels of PRPP is characterized by the overproduction and accumulation of uric acid leading to hyperuricemia and hyperuricosuria. It is one of the causes of gout.

Increased levels of PRPP are present in Lesch-Nyhan Syndrome. Decreased levels of hypoxanthine guanine phosphoribosyl transferase (HGPRT) causes this accumulation, as PRPP is a substrate used by HGPRT during purine salvage.

See also

Template:Nucleotide metabolism intermediates

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sv:Fosforibosylpyrofosfatsyntetas