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Open Access Articles- Top Results for Phosphorylase kinase, alpha 1

Phosphorylase kinase, alpha 1

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Identifiers
SymbolsPHKA1 ; PHKA
External IDsOMIM311870 MGI97576 HomoloGene1981 ChEMBL: 2905 GeneCards: PHKA1 Gene
EC number2.7.11.19
Orthologs
SpeciesHumanMouse
Entrez525518679
EnsemblENSG00000067177ENSMUSG00000034055
UniProtP46020P18826
RefSeq (mRNA)NM_001122670NM_008832
RefSeq (protein)NP_001116142NP_032858
Location (UCSC)Chr HG1438_PATCH:
71.8 – 71.93 Mb
Chr X:
102.51 – 102.64 Mb
PubMed search[1][2]

Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform is an enzyme that in humans is encoded by the PHKA1 gene.[1]

The PHKA1 gene encodes the alpha subunit of muscle phosphorylase kinase (EC 2.7.1.38), a key regulatory enzyme of glycogen metabolism. Phosphorylase kinase consists of 4 copies of an alpha-beta-gamma-delta tetramer. The alpha, beta (PHKB; MIM 172490), and gamma (PHKG1; MIM 172470 and PHKG2; MIM 172471) subunits have several isoforms; the delta subunit is calmodulin (CALM1; MIM 114180). PHKA2 (MIM 306000) encodes the alpha subunit of liver-specific phosphorylase kinase and is also located on the X chromosome.[supplied by OMIM][1]

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