Open Access Articles- Top Results for Phrenic nerve

Phrenic nerve

"Phrenectomy" redirects here. It is not to be confused with frenectomy, removal of a frenulum.
Phrenic nerve
The phrenic nerve and its relations with the vagus nerve. (Phrenic labeled at upper left and right.)
Plan of the cervical plexus. (Phrenic labeled at bottom right.)
Latin nervus phrenicus
C3-C5 of cervical plexus
Innervates Diaphragm
Gray's p.928
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Anatomical terms of neuroanatomy

The phrenic nerve is a nerve that originates in the neck (C3-C5) and passes down between the lung and heart to reach the diaphragm. It is important for breathing, as it passes motor information to the diaphragm and receives sensory information from it. There are two phrenic nerves, a left and a right one.

The phrenic nerve originates mainly from the 4th cervical nerve, but also receives contributions from the 5th and 3rd cervical nerves (C3-C5) in humans.[1] Thus, the phrenic nerve receives innervation from parts of both the cervical plexus and the brachial plexus of nerves.

The phrenic nerves contain motor, sensory, and sympathetic nerve fibers. These nerves provide the only motor supply to the diaphragm as well as sensation to the central tendon. In the thorax, each phrenic nerve supplies the mediastinal pleura and pericardium.


The phrenic nerve descends obliquely with the internal jugular vein across the anterior scalene, deep to the prevertebral layer of deep cervical fascia and the transverse cervical and suprascapular arteries. On the left, the phrenic nerve crosses anterior to the first part of the subclavian artery. On the right, it lies on the anterior scalene muscle and crosses anterior to the 2nd part of the subclavian artery. On both sides, the phrenic nerve runs posterior to the subclavian vein as it enters the thorax where it runs anterior to the root of the lung and into the pericardium between the fibrous and parietal layers.[1]

Found in the middle mediastinum, both phrenic nerves run from C3, C4, and C5 along the anterior scalene muscle deep to the carotid sheath.

The pericardiacophrenic arteries and veins travel with their respective phrenic nerves.

The phrenic nerve can be marked by a line connecting these two points:

  1. 1st point can be labelled 3.5 cm at the level of the thyroid cartilage from the midsagittal plane.
  2. 2nd point is at the medial end of the clavicle.


The contribution of the 5th cervical nerve may stem from an accessory phrenic nerve. Phrenic nerve in its early course close to its origin, was giving a communicating branch to C5 root of brachial plexus. The phrenic nerve at the level of root of neck just before entering the thorax was placed in front of the subclavian vein. Usually it is placed posterior in between subclavian vein and artery.[2]

Most often it is a branch of the nerve to the subclavius and may contain numerous phrenic nerve fibers. If the accessory phrenic nerve is present, it lies lateral to the main nerve and descends posterior and occasionally inferior to the subclavian vein. The accessory phrenic nerve connects to the phrenic nerve in the thorax or the root of the neck.[1]


Both of these nerves supply motor fibres to the diaphragm and sensory fibres to the fibrous pericardium, mediastinal pleura, and diaphragmatic peritoneum.

Clinical significance

Pain arising from structures served by the phrenic nerve is often "referred" to other somatic regions served by spinal nerves C3-C5. For example, a subphrenic abscess beneath the right diaphragm might cause a patient to feel pain in the right shoulder.

Irritation of the phrenic nerve (or the tissues supplied by it) leads to the hiccough reflex. A hiccough is a spasmodic contraction of the diaphragm, which pulls air against the closed folds of the larynx.

The phrenic nerve must be identified during thoracic surgery and preserved. It passes anterior to the hilum of the corresponding lung, and therefore can be identified easily. The right phrenic nerve may be crushed by the vena cava clamp during liver transplantation.[3] Severing the phrenic nerve, or a phrenectomy,[4] will paralyse that half of the diaphragm. Diaphragm paralysis is best demonstrated by sonography.[3] Breathing will be made more difficult but will continue provided the other nerve is intact.

The phrenic nerve arises from the neck (C3-C5) and innervates the diaphragm, which is much lower. Hence, patients suffering spinal cord injuries below the neck are still able to breathe effectively, despite any paralysis of the lower limbs.

Additional images

See also

This article uses anatomical terminology; for an overview, see anatomical terminology.


  1. ^ a b c Moore, Keith L. (1999). Clinically oriented anatomy. Philadelphia: Lippincott Williams & Wilkins. ISBN 0-683-06141-0. [page needed]
  2. ^ Prakash; Prabhu, L. V.; Madhyastha, S; Singh, G (2007). "A variation of the phrenic nerve: Case report and review" (PDF). Singapore Medical Journal 48 (12): 1156–7. PMID 18043847. 
  3. ^ a b McAlister, Vivian C.; Grant, David R.; Roy, Andre; Brown, William F.; Hutton, Linda C.; Leasa, David J.; Ghent, Cameron N.; Veitch, James E.; Wall, William J. (1993). "Right phrenic nerve injury in orthotopic liver transplantation". Transplantation 55 (4): 826–30. PMID 8475559. 
  4. ^ Hine, Maynard Kiplinger (1975). Review of dentistry: questions and answers (6th ed.). Mosby. p. 421. ISBN 0-8016-2196-8. 

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