Open Access Articles- Top Results for Piclozotan


Systematic (IUPAC) name
Clinical data
  • Uncontrolled
182415-09-4 7pxY
PubChem CID 9801640
ChemSpider 7977402 7pxN
Chemical data
Formula C23H24ClN3O2
409.909 g/mol
 14pxN (what is this?)  (verify)

Piclozotan (SUN-N4057) is a selective 5-HT1A receptor partial agonist, which has neuroprotective effects in animal studies.[1] It has been through early clinical trials in humans for treatment of acute stroke, but results have not yet been announced.[2][3]

See also


  1. Kamei, K.; Maeda, N.; Nomura, K.; Shibata, M.; Katsuragi-Ogino, R.; Koyama, M.; Nakajima, M.; Inoue, T.; Ohno, T.; Tatsuoka, T. (2006). "Synthesis, SAR studies, and evaluation of 1,4-benzoxazepine derivatives as selective 5-HT1A receptor agonists with neuroprotective effect: Discovery of Piclozotan". Bioorganic & Medicinal Chemistry 14 (6): 1978–1992. PMID 16290165. doi:10.1016/j.bmc.2005.10.046.  edit
  2. Ferro, J.; Dávalos, A. (2006). "Other neuroprotective therapies on trial in acute stroke". Cerebrovascular diseases (Basel, Switzerland). 21 Suppl 2 (2): 127–130. PMID 16651823. doi:10.1159/000091712.  edit
  3. Mondick, J.; Oo, C.; Patel, D.; Fujitani, T.; Shimizu, K.; Barrett, J. (2009). "Population pharmacokinetics of the selective serotonin 5-HT1A receptor partial agonist piclozotan". American journal of therapeutics 16 (2): 106–115. PMID 19300037. doi:10.1097/MJT.0b013e31816b8c85.  edit

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