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Open Access Articles- Top Results for Piretanide

Piretanide

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Piretanide
File:Piretanide.png
Systematic (IUPAC) name
3-(aminosulfonyl)-4-phenoxy-5-pyrrolidin-1-ylbenzoic acid
Clinical data
Trade names Arelix, Eurelix, Tauliz
AHFS/Drugs.com International Drug Names
  • (Prescription only)
Oral
Identifiers
55837-27-9 7pxY
C03CA03
PubChem CID 4849
DrugBank DB02925 7pxN
ChemSpider 4683 7pxN
UNII DQ6KK6GV93 7pxY
KEGG D01634 7pxY
Chemical data
Formula C17H18N2O5S
362.40 g/mol
 14pxN (what is this?)  (verify)

Piretanide (INN, trade names Arelix, Eurelix, Tauliz) has been synthesized in 1973 at Hoechst AG (Germany) as a loop diuretic[1] compound by using a then-new method for introducing cyclic amine residues in an aromatic nucleus in the presence of other aromatically bonded functional groups. Studies of piretanide in rats and dogs in comparison with other high-ceiling diuretics such as furosemide and bumetanide found a more suitable dose/response rate (regression line) and a more favourable sodium/potassium excretion ratio. These findings led eventually to clinical studies in man and finally to the introduction as a saluretic and antihypertensive[2] medication in Germany, France, Italy and other countries.

References

  1. ^ Musini, V. M.; Wright, J. M.; Bassett, K.; Jauca, C. D. (2009). Musini, Vijaya M, ed. "Blood pressure lowering efficacy of loop diuretics for primary hypertension". The Cochrane Library (4): CD003825. PMID 19821314. doi:10.1002/14651858.CD003825.pub2.  edit
  2. ^ Haberfeld, H, ed. (2009). Austria-Codex (in German) (2009/2010 ed.). Vienna: Österreichischer Apothekerverlag. ISBN 3-85200-196-X. 
  • W.Merkel, D.Bormann, D.Mania, R.Muschaweck and M.Hropot, Eur. J. Med. Chem.-Chim.Ther. 11,399 (1976).
  • W.Merkel, D.Mania and D.Bormann, Liebigs Ann. Chem. 461 (1979).


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