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Open Access Articles- Top Results for Pirlindole

Pirlindole

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Pirlindole
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Systematic (IUPAC) name
8-methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole
Clinical data
Trade names Pirazidol
  • (Prescription only)
Oral
Pharmacokinetic data
Bioavailability 20–30%
Protein binding 95%
Metabolism hepatic
Onset of action 2 to 8 hours
Half-life 185 hours
Excretion urine (50–70%), feces (25–45%)
Identifiers
60762-57-4
None
PubChem CID 68802
ChemSpider 62039
UNII V39YPH45FZ 7pxY
KEGG D08392
ChEMBL CHEMBL32350
Chemical data
Formula C15H18N2
226.32 g/mol

Pirlindole (Lifril, Pyrazidol) is a reversible inhibitor of monoamine oxidase A (RIMA) which was developed and is used in Russia as an antidepressant.[1]:337 It is structurally and pharmacologically related to metralindole.

See also

References

  1. ^ Medvedev AE, et al. The influence of the antidepressant pirlindole and its dehydro-derivative on the activity of monoamine oxidase A and GABAA receptor binding. Chapter 36 in MAO - The Mother of all Amine Oxidases (Journal of Neural Transmission. Supplementa). Eds Finberg JPM, Youdim MBH, Riederer P, Tipton KF. Special edition of Journal of Neural Transmission, Suppl. 52 1st ed. 1998 ISBN 978-3211830376


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