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Open Access Articles- Top Results for Pridefine

Pridefine

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Pridefine
File:Pridefine.png
Systematic (IUPAC) name
3-(diphenylmethylidene)-1-ethylpyrrolidine
Clinical data
  • Uncontrolled
Oral
Identifiers
5370-41-2
None
PubChem CID 31740
ChemSpider 29434
UNII W0394470AX 7pxY
Chemical data
Formula C19H21N
263.38 g/mol

Pridefine (AHR-1,118) is a drug which was investigated as an antidepressant in the late 1970s and early 1980s but was never marketed.[1] It acts as a balanced reuptake inhibitor of serotonin, dopamine, and norepinephrine, and also has some weak releasing activity.[1][2][3]

In clinical trials pridefine was found to be as efficacious as the tricyclic antidepressants amitriptyline and imipramine in the treatment of major depressive disorder but was much more tolerable in comparison and also had an earlier onset of action.[1] It has been shown to be effective in the treatment of alcoholism as well.[1]

Synthesis

See also

References

  1. ^ a b c d Vosmer G, DeMet EM, Halaris AE (1980). "Action of the antidepressant pridefine (AHR-1118) on biogenic amines in the rat brain". Biochemical Pharmacology 29 (19): 2557–62. PMID 7426062. doi:10.1016/0006-2952(80)90066-0. 
  2. ^ Halaris AE, Demet EM (1980). "Open trial evaluation of a pyrrolidine derivative (AHR-1118) on norepinephrine metabolism". Progress in Neuro-psychopharmacology 4 (1): 43–9. PMID 7406986. doi:10.1016/0364-7722(80)90060-0. 
  3. ^ DeMet EM, Vosmer G, Halaris AE (1981). "Noncompetitive amine uptake inhibition by the new antidepressant pridefine". Journal of Neurochemistry 36 (3): 917–23. PMID 7205281. doi:10.1111/j.1471-4159.1981.tb01682.x. 
  4. ^ El-Abbady, A. M.; Mousa, H. H. (1965). "Studies on stobbe condensation: reactions of aldehydes and ketones with dimethyl methylsuccinate". Canadian Journal of Chemistry 43 (4): 928–934. doi:10.1139/v65-119. 
  5. ^ Ohki, Sadao; Ozawa, Naganori; Yabe, Yuichiro; Matsuda, Hideaki (1976). "Anthicholinergic agents. Synthesis of 1,1,4-trimethyl- and 1,1,5-trimethyl-3-diphenylmethylenepyrrolidinium halides". Chemical and Pharmaceutical Bulletin 24 (6): 1362–1370. doi:10.1248/cpb.24.1362.