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Proglumetacin

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Proglumetacin
File:Proglumetacin.svg
Systematic (IUPAC) name
3-{4-[2-({[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}oxy)ethyl]piperazin-1-yl}propyl N2-benzoyl-N,N-dipropyl-α-glutaminate
Clinical data
AHFS/Drugs.com International Drug Names
Pharmacokinetic data
Metabolism Hepatic. Undergoes enterohepatic recirculation
Identifiers
57132-53-3 59209-40-4
M01AB14
PubChem CID 4921
ChemSpider 4752 7pxY
UNII FV919079LU 7pxY
ChEBI CHEBI:76263
Synonyms 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-(benzoylamino)-5-(dipropylamino)-5-oxopentanoate
Chemical data
Formula C46H58ClN5O8
844.43442 g/mol
 14pxY (what is this?)  (verify)

Proglumetacin (usually as the maleate salt, trade names Afloxan, Protaxon and Proxil) is a non-steroidal anti-inflammatory drug. It is metabolized in the body to indometacin and proglumide,[1] a drug with antisecretory effects that helps prevent injury to the stomach lining.

References

  1. Setnikar I, Arigoni R, Chisté R, Makovec F, Revel L (1987). "Plasma levels of proglumetacin and its metabolites after intravenous or oral administration in the dog". Arzneimittel-Forschung 37 (6): 698–702. PMID 3663267. 


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