Open Access Articles- Top Results for Propacetamol


Systematic (IUPAC) name
4-(acetamido)phenyl N,N-diethylglycinate
Clinical data
AHFS/ International Drug Names
Pharmacokinetic data
Half-life 2.4 hours [1]
Excretion Renal
PubChem CID 68865
ChemSpider 62097
Chemical data
Formula C14H20N2O3
264.3202 g/mol
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Propacetamol is a prodrug form of paracetamol which is formed from esterification of paracetamol, and the carboxylic acid diethylglycine. This has the advantage of making it more water-soluble. It is used in post-operative care and is delivered by I.V.[2] It is given if the patient is unable to take oral or rectally delivered paracetamol and non-steroidal anti-inflammatory drugs are contraindicated. The onset of analgaesia from propacetamol is more rapid than paracetamol given orally.[3] 2 g of propacetamol are equivalent to 1g of paracetamol.[4]

See also


  1. ^ a b Bannwarth B, Netter P, Lapicque F, Gillet P, Péré P, Boccard E, Royer RJ, Gaucher A (1992). "Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol" (PDF). British Journal of Clinical Pharmacology 34 (1): 79–81. PMC 1381380. PMID 1633071. doi:10.1111/j.1365-2125.1992.tb04112.x. 
  2. ^ a b Binhas M, Decailliot F, Rezaiguia-Delclaux S, Suen P, Dumerat M, François V, Combes X, Duvaldestin P (2004). "Comparative effect of intraoperative propacetamol versus placebo on morphine consumption after elective reduction mammoplasty under remifentanil-based anesthesia: a randomized control trial [ISRCTN71723173]" (PDF). BMC Anesthesiology 4 (1): 6. PMC 520811. PMID 15367329. doi:10.1186/1471-2253-4-6. 
  3. ^ Moller PL, Sindet-Pedersen S, Petersen CT, Juhl GI, Dillenschneider A, Skoglund LA (2005). "Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery" (PDF). British Journal of Anaesthesiology 94 (5): 642–648. PMID 15790675. doi:10.1093/bja/aei109. 
  4. ^ Flouvat B, Leneveu A, Fitoussi S, Delhotal-Landes B, Gendron A (2004). "Bioequivalence study comparing a new paracetamol solution for injection and propacetamol after single intravenous infusion in healthy subjects". International Journal of Clinical Pharmacology and Therapeutics 42 (1): 50–57. PMID 14756388. doi:10.5414/cpp42050. 

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