Open Access Articles- Top Results for Protein kinase, AMP-activated, alpha 1

Protein kinase, AMP-activated, alpha 1

SymbolsPRKAA1 ; AMPK; AMPKa1
External IDsOMIM602739 MGI2145955 HomoloGene49590 IUPHAR: 1541 ChEMBL: 4045 GeneCards: PRKAA1 Gene
EC number2.7.11.1,,,
RNA expression pattern
File:PBB GE PRKAA1 209799 at tn.png
More reference expression data
RefSeq (mRNA)NM_006251NM_001013367
RefSeq (protein)NP_006242NP_001013385
Location (UCSC)Chr 5:
40.76 – 40.8 Mb
Chr 15:
5.14 – 5.18 Mb
PubMed search[1][2]

5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene.[1][2]

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[2]


Protein kinase, AMP-activated, alpha 1 has been shown to interact with TSC2.[3][4]


  1. ^ Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE (Feb 1996). "Mammalian AMP-activated protein kinase subfamily". J Biol Chem 271 (2): 611–4. PMID 8557660. doi:10.1074/jbc.271.2.611. 
  2. ^ a b "Entrez Gene: PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit". 
  3. ^ Inoki, Ken; Zhu Tianqing; Guan Kun-Liang (Nov 2003). "TSC2 mediates cellular energy response to control cell growth and survival". Cell (United States) 115 (5): 577–90. ISSN 0092-8674. PMID 14651849. doi:10.1016/S0092-8674(03)00929-2. 
  4. ^ Shaw, Reuben J; Bardeesy Nabeel; Manning Brendan D; Lopez Lyle; Kosmatka Monica; DePinho Ronald A; Cantley Lewis C (Jul 2004). "The LKB1 tumor suppressor negatively regulates mTOR signaling". Cancer Cell (United States) 6 (1): 91–9. ISSN 1535-6108. PMID 15261145. doi:10.1016/j.ccr.2004.06.007. 

Further reading


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