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Proxymetacaine

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Proxymetacaine
File:Proxymetacaine structure.svg
Systematic (IUPAC) name
2-(diethylamino)ethyl 3-amino-4-propoxybenzoate
Clinical data
AHFS/Drugs.com International Drug Names
  • US: C (Risk not ruled out)
Topical (eye drops)
Pharmacokinetic data
Metabolism Plasma
Identifiers
499-67-2 7pxY
5875-06-9 (HCl)
S01HA04
PubChem CID 4935
DrugBank DB00807 7pxY
ChemSpider 4766 7pxY
UNII B4OB0JHI1X 7pxY
KEGG D08448 7pxY
ChEMBL CHEMBL1196 7pxY
Chemical data
Formula C16H26N2O3
294.389 g/mol
 14pxY (what is this?)  (verify)

Proxymetacaine (INN) or proparacaine (USAN) is a topical anesthetic drug of the aminoester group.

Clinical pharmacology

Indications and usage

Proxymetacaine hydrochloride ophthalmic solution (eye drops) is indicated for procedures such as tonometry, gonioscopy, removal of foreign bodies, or other similar procedures requiring topical anesthesia of the cornea and conjunctiva.

Warnings

Proxymetacaine is for topical ophthalmic use only, and it is specifically not intended for injection. Prolonged use of this or any other topical ocular anesthetic may produce permanent corneal opacification with accompanying visual loss.

Mechanism of action

Proxymetacaine is believed to act as an antagonist on voltage-gated sodium channels to affect the permeability of neuronal membranes; how this inhibits pain sensations and the exact mechanism of action of proxymetacaine are, however, unknown.

How supplied

Proxymetacaine is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%. Although it is no longer on patent, it is still marketed under the trade names Alcaine, Ak-Taine, and others.


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